• Anti-Tau [pS422] Monoclonal Antibody
Anti-Tau [pS422] Monoclonal Antibody-clone 2H9
Product Specifications
Research Area Neuroscience
Purity Mouse monoclonal antibodies 2H9 was purified by protein A/G affinity chromatography. Purity > 90%, as determined by SDS- PAGE and visualized by Coomassie blue staining.
Host Species Mouse
Reactive Species Human,Mouse,Rat
Target Tau [pS422]
Tested Applications WB,IF,IHC,FCM
Clonality Monoclonal
Isotype IgG2a Kappa
Conjuation Label Unconjugated
Sample Types Cells,Tissues
Physical Format Liquid Form
Shipping Conditions Room Temperature
Storage Conditions (-)20 deg.C
Clone Name clone 2H9
Storage Buffer PBS
Formulation Solution in PBS at 1 mg/mL
Regulatory Information RUO
Technical Notes WB: 0.2 µg/mL IHC / IF : 2 µg/mL (working with cells, tissue sections (frozen and paraffin-embedded)
Application Notes Research Use Only Product (RUO) / Not for Diagnosis or Therapeutic Use.
Application Tau proteins are encoded by a single gene MAPT (Gene ID: 4137). They belong to the family of microtubule-associated proteins. The phosphorylation of Tau protein at serine 422 is a pathological epitope and a specific marker of neurofibrillary degeneration, one of the neuropathological hallmark of Alzheimer’s disease and also found in more than 20 Tauopathies. On cerebral tissue, frozen or paraffin embedded tissue, 2H9 Tau antibody detects neurons in neurofibrillary degeneration. The serine 422 is phosphorylated by the following kinases: CaMKII (Calcium Calmodulin-kinase II), PKA (protein kinase A), JNKs (c-Jun N-terminal kinases), ERK1/2 or p42/44 MAKP (mitogen-activated kinases), p38 MAPK and MARK (Microtubule-associated protein/microtubule affinity-regulating kinase).
Articles & Publications Lam S, Petit F, Hérard AS, Boluda S, Eddarkaoui S, Guillermier M, The Brainbank Neuro-CEB Neuropathology Network, Buée L, Duyckaerts C, Haïk S, Picq JL, Dhenain M (2021) Amyloid and tau pathologies, cognitive impairments and cerebral atrophy after Alzheimer brain extracts inoculation in a primate. Acta Neuropathol Commun. in press Lam S, Boluda S, Hérard AS, Petit F, Eddarkaoui S,Cambon K, The Brainbank Neuro-CEB Neuropathology Network, Picq JL, Buee L, Duyckaerts C, Haïk S and Dhenain M (2021) Alzheimer’s brain inoculation in Aß-plaque bearing mice: synaptic loss is linked to tau seeding and low microglial activity. BioRxiv preprint doi: https://doi.org/10.1101/2021.04.06.438654; Tautou M, Eddarkaoui S, Descamps F, Larchanché P-E, El Bakali J, Goveas LM, Dumoulin M, Lamarre C, Blum D, Buée L, Melnyk P and Sergeant N (2021) A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory ina Mouse Model of Neurofibrillary Degeneration. Front. Pharmacol. Vol 12:679335. doi: 10.3389/fphar.2021.679335 Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D and Buee L (2012) Targeting phospho-Ser422 by active Tau Immunotherapy in the THY-Tau22 mouse model: a suitable therapeutic approach. Curr Alzheimer Res. 9(4):397-405. Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P (2019). New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease. Neurobiol Dis. Vol. 129:217-233. Sergeant N, Bretteville A, Hamdane M, Caillet-Boudin ML, Grognet P, Bombois S, Blum D, Delacourte A, Pasquier F, Vanmechelen E , Schraen-Maschke S, and Buee L (2008) Biochemistry of Tau in Alzheimer’s disease and related neurological disorders. Expert review of proteomics 5:207–224.

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Anti-Tau [pS422] Monoclonal Antibody

  • Brand: 4BioDx
  • Product Code: 4BioDx-4BDX-1501S
  • Availability: Pre-Order

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Tags: Tau, Amyloid