ENDOTOXIN LEVEL <0.1 EU per 1 μg of the protein by the LAL method. Human Recombinant GMP Grade IL-6 (Interleukin-6). Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene. In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1RA and IL-10.
| Product Specifications | |
| Research Area | 2D-3D Cell Culture,Cell Therapy |
| Purity | >98% by SDS-PAGE |
| Target | IL-6 |
| Tested Applications | Cell Culture,Cell Therapy |
| Conjuation Label | His-Tag |
| Grade | GMP Grade |
| Physical Format | Lyophilized |
| Animal Free | Yes |
| Source(Natural/Synthetic) | Recombinant |
| Origin | E.coli |
| Sterile | Sterile |
| Animal Model | Human |
| Shipping Conditions | Blue Ice |
| Storage Conditions | Store at -20degC |
| Storage Buffer | 1X PBS-pH8.0 |
| UniProtKB | P05231 |
| Protein Type | Bioactive |
| Technical Notes | Protein Sequence - MVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEF EVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM with polyhistidine tag at the C-terminus |
| Application Notes | BIOACTIVITY-Measure by its ability to induce proliferation in TF-1 cells The ED50 for this effect is <0.5 ng/mL. The specific activity of recombinant human IL-6 is approximately >5 x 108 IU/mg. Measure by its ability to induce proliferation in MCF-7 cells. The ED50 for this effect is <4.4 ng/mL. |
Human IL-6 (Interleukin-6) His-Tag GMP Grade Recombinant Protein
- Brand: Croyez
- Product Code: Croyez-C01008-GMP-1000
- Availability: Pre-Order