ENDOTOXIN LEVEL <0.1 EU per 1 μg of the protein by the LAL method. Human Recombinant GMP Grade Noggin. Noggin is a bioactive protein intended for use in cell culture applications. Noggin protein which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures.
| Product Specifications | |
| Research Area | 2D-3D Cell Culture,Cell Therapy |
| Purity | >98% by SDS-PAGE |
| Target | Noggin |
| Tested Applications | Cell Culture,Cell Therapy |
| Conjuation Label | His-Tag |
| Grade | GMP Grade |
| Physical Format | Lyophilized |
| Animal Free | Yes |
| Source(Natural/Synthetic) | Recombinant |
| Origin | E.coli |
| Sterile | Sterile |
| Animal Model | Human |
| Shipping Conditions | Blue Ice |
| Storage Conditions | Store at -20degC |
| Storage Buffer | 1X PBS-pH8.0 |
| UniProtKB | Q13253 |
| Protein Type | Bioactive |
| Technical Notes | Protein Sequence - MQHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGAAGGAEDLAELDQLLRQRPSGAMP SEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC QRRGGQRCGWIPIQYPIISECKCSC with polyhistidine tag at the C-terminus |
| Application Notes | BIOACTIVITY-Measure by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is <0.05 μg/mL in the presence of 50 ng/mL of recombinant human BMP-4. |
Human Noggin His-Tag GMP Grade Recombinant Protein
- Brand: Croyez
- Product Code: Croyez-C01176-GMP-100
- Availability: Pre-Order
Available Options
Tags: Noggin