The human bioactive Sclerostin (SOST) Sandwich ELISA kit is a quick day test intended for the quantitative measurement of bioactive Sclerostin levels in human serum and plasma samples (EDTA and citrate). The bioactive SOST ELISA specifically recognizes the Sclerostin osteoclast interacting (functional) domain.
This kit has been cited in >20 publications to date.
Target Information: Canonical Wnt-signalling plays an important role in the regulation of bone homeostasis by promoting the development of osteoblasts. Negative regulators of the Wnt pathway are important therapeutic targets for the treatment of diseases with enhanced bone resorption. One of these molecules is Sclerostin, a 22.5 kD secreted glycoprotein, which acts by binding to the Wnt-coreceptor LRP5 thus preventing the binding of Wnt molecules.
| Product Specifications | |
| Research Area | Bone Metabolism,Cardiovascular,Nephrology |
| Assay Type | ELISA Kit |
| Reactive Species | Human |
| Target | Sclerostin |
| Sample Types | Serum,Plasma |
| Shipping Conditions | Blue Ice |
| Storage Conditions | 2-8 deg.C |
| Sensitivity | 42.7 pg/ml (=1.9 pmol/l) |
| Assay Time | 3.5 hrs |
| Percision CV% | intra-assay: 1%, inter-assay: 5% |
| Molecular Weight | 22.5 kDa |
| Detection Method | ELISA |
| Assay Range | 225-7,200 pg/ml (=10-320 pmol/l) |
| Regulatory Information | RUO |
| Technical Notes | Precision(intra-assay: 1%, inter-assay: 5%) |
| Application Notes | Sample Vol :20µl/well |
| Articles & Publications | Widely cited and certified; references available upon request. |
Human bioactive Sclerostin (SOST) ELISA
- Brand: BMG
- Product Code: BMG-BI-20472
- Availability: Pre-Order
Available Options
Tags: Sclerostin, SOST, Sclerosteosis, bioactive_Sclerostin, Sclerostin_ELISA